ULTIMATE PROTECTION FOR SPRAY VACCINATION
Spray-Vac® Poultry Spray Vaccine Stabilizer
Protect Your Vaccine Investment
Spray-Vac® is a vaccine stabilizer developed by Animal Science Products to help protect the viability of poultry vaccines administered through spray vaccination systems.
Water quality plays an important role in maintaining live vaccine stability. Chlorine and other oxidizers, pH imbalance, and low tonicity can threaten vaccine viability during preparation and application.
Spray-Vac addresses these three water-quality challenges, helping poultry producers prepare stabilized spray solutions using suitable tap or well water rather than relying exclusively on distilled water.
Protection Against Three Water-Quality Threats
Oxidizers • pH Imbalance • Low Tonicity
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Protecting Vaccines From Three Water-Quality Threats
The water used to prepare poultry spray vaccines can affect vaccine stability. Even distilled water may present challenges related to pH and low tonicity.
Spray-Vac® is formulated to address three important water-quality threats that can compromise vaccine viability.
Oxidizers
Protecting Live Vaccines From Chlorine
Chlorine and other oxidizing compounds in water can damage live vaccine organisms.
Spray-Vac helps protect vaccines from chlorine-related inactivation, allowing suitable chlorinated water to be used in spray vaccine preparation.
pH Imbalance
Helping Maintain a More Suitable pH
Water that is too acidic or too alkaline can threaten vaccine stability.
Spray-Vac contains a buffering system designed to adjust spray-solution pH toward a more suitable range for vaccine preservation.
Low Tonicity
Supporting the Stability of Fragile Vaccine Organisms
Low-tonicity water can create osmotic stress for fragile vaccine organisms, particularly live whole-cell bacterial vaccines.
Spray-Vac helps correct spray-solution tonicity to reduce this threat to vaccine stability.
How Spray-Vac Supports Vaccine Stability
Stabilizing the Water Before It Reaches the Vaccine
Maintaining vaccine viability during preparation and spray application begins with the quality of the water used as the diluent.
Spray-Vac® combines three stabilizing functions to help create a more suitable environment for fragile poultry vaccines.
Neutralizing Oxidizers
Spray-Vac protects live vaccine organisms from the damaging effects of chlorine in spray water. Research with infectious bronchitis and Newcastle disease vaccines demonstrated protection against chlorine-related reductions in live vaccine titers.
Buffering Water pH
Spray-Vac's buffering system helps adjust acidic or alkaline water toward a more suitable pH for vaccine stability.
Correcting Low Tonicity
Spray-Vac helps correct low-tonicity conditions that can threaten the integrity of fragile whole-cell bacterial vaccines.
One Stabilizer. Three Forms of Protection.
By addressing oxidizers, pH imbalance, and low tonicity together, Spray-Vac helps reduce important water-related threats to vaccine viability during poultry spray vaccination.
Untreated Spray Water
Potential water-quality threats to vaccine stability
Protection
Buffering
Adjustment
Stabilized Spray Solution
Reduced water-related threats to vaccine viability
Research-Backed Vaccine Protection
Demonstrated Stability in Live Poultry Vaccines
Research conducted with live infectious bronchitis (IB) and Newcastle disease (ND) vaccines demonstrates the importance of protecting vaccine viability when chlorinated water is used for spray vaccination.
In controlled laboratory studies, Spray-Vac® helped maintain live vaccine titers in water containing chlorine, while unstabilized vaccine preparations experienced substantial reductions in viability.
The following studies illustrate how Spray-Vac performed under the specific experimental conditions tested.
Infectious Bronchitis Vaccine Stability
Live vaccine titers in water containing 4 ppm chlorine
Spray-Vac maintained the reported infectious bronchitis vaccine titer at approximately 104.5 EID50/dose at both time points.
Source: Vaccine Stabilizer Brochure, p. 3, Figure 2. Laboratory results under specified experimental conditions.
Newcastle Disease Vaccine Stability
Live vaccine titers in water containing 4 ppm chlorine
Spray-Vac-treated vaccine maintained titers of 105.5 and 105.2 EID50/dose at 30 and 120 minutes, respectively.
*Unstabilized titers were at or below the study's lower quantification limit of 104.5. Gray bars show this limit, not exact measured titers. Source: Newcastle Vaccine Stability Improvement, p. 2, Study 1.
Spray-Vac Protection for Fragile Mycoplasma Vaccines
Supporting the Stability of Live Bacterial Vaccines
In addition to the viral vaccine research, Spray-Vac® has been evaluated for its ability to protect fragile live mycoplasma vaccines from water-related threats.
Research described in the Spray-Vac technical brochure examined the effects of chlorinated water on live mycoplasma vaccine stability.
The reported findings showed that chlorinated water without stabilizer inactivated the vaccine in less than 15 minutes, while Spray-Vac protected vaccine viability for at least 60 minutes under the experimental conditions.
Why Tonicity Matters
Live whole-cell bacterial vaccines can be particularly sensitive to low-tonicity water.
When the surrounding solution lacks sufficient electrolytes, water can enter bacterial cells through their membranes, potentially causing swelling and damage.
Spray-Vac helps correct low-tonicity conditions, providing a more suitable environment for fragile vaccine organisms.
Additional Research Into Frozen Mycoplasma Vaccines
ASP has also published research discussing the use of Spray-Vac in an experimental frozen mycoplasma vaccine preparation.
This research represents a separate application from routine spray vaccination and should not be interpreted as an established preparation method for commercially available frozen vaccines.
Mycoplasma Vaccine Stability
Reported experimental findings in chlorinated water
Reported vaccine inactivation
Reported protection of vaccine viability
Source: Spray-Vac Vaccine Stabilizer Brochure. Findings reflect the reported experimental conditions and are not a general vaccine stability guarantee.
Spray-Vac® Benefits and Application
Designed to Support Live Poultry Spray Vaccination
Spray-Vac® is formulated to help protect live poultry vaccines from water-quality conditions that can affect vaccine stability during preparation and application.
Three Areas of Water-Quality Protection
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Oxidizer Neutralization: Helps protect live vaccines from oxidizing agents such as chlorine in preparation water.
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pH Buffering: Helps manage acidic or alkaline water conditions that may affect vaccine stability.
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Tonicity Support: Provides electrolytes to help address low-tonicity conditions that can be particularly damaging to fragile live bacterial vaccines.
By addressing these three water-quality factors, Spray-Vac helps provide a more suitable environment for live vaccines during spray vaccination.
Spray-Vac® Application
Follow the applicable product label and vaccine manufacturer's instructions when preparing vaccines for spray administration.
Prepare the Water
Begin with water suitable for vaccine preparation, following the vaccine manufacturer's instructions.
Add Spray-Vac®
Use Spray-Vac according to the dosage, preparation sequence, and directions provided on the current product label.
Prepare & Apply the Vaccine
Prepare and administer the vaccine according to the vaccine manufacturer's instructions and applicable Spray-Vac label directions.
Important: Always consult the current Spray-Vac product label and the vaccine manufacturer's instructions for specific preparation, dosage, compatibility, and application requirements.
Technical Resources & Supporting Research
Explore technical information and research related to poultry vaccine stabilization, water quality, and Spray-Vac®.
Vaccine Stabilizer Brochure
A broader technical reference covering poultry vaccination management, water-quality challenges, vaccine stabilizers, and supporting research.
View BrochureNewcastle Disease Vaccine Stability
Research examining the stability of live Newcastle disease vaccine in chlorinated water, including experimental comparisons with Spray-Vac.
View ResearchFrozen Mycoplasma Vaccine Research
An ASP article discussing experimental research involving Spray-Vac and frozen poultry mycoplasma vaccine preparations, distinct from routine spray vaccination.
Read ArticleResearch findings reflect the specific experimental conditions described in each source. Refer to the current Spray-Vac product label and vaccine manufacturer's instructions for application guidance.
Questions About Spray-Vac?
Learn more about Spray-Vac applications, technical research, and product information for hatchery vaccination programs.
Contact Animal Science Products to discuss Spray-Vac with our team using our form below.
Additional Information and Related Articles on Spray-Vac®
SpecSheet | SpecSheet Spanish | SpecSheet Modern Chinese | SDS | SDS Chinese | SDS Spanish Spray-Vac Stabilizer aids in the administration of sprayed vaccines for poultry. It is especially designed to prolong the viability and improve the effectiveness of reconstituted and diluted spray vaccines.
RELATED ARTICLES:
Newcastle Vaccine Stability Improvement Article
Spray-Vac Stabilizes Frozen Poultry Mycoplasma PDF | ARTICLE
Vaccine Stabilizer Brochure
Vaccine Stabilizer Brochure Spanish
Vaccine Stabilizer Brochure Chinese
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PO Drawer 631408
Nacogdoches, TX 75963 - 1408
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Nacogdoches, Texas 75961
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